Your newsletter has just gone out and your inbox is filling up with out-of-office auto-responder messages. Are you deleting them unopened? They might be worth a closer look.
Other than vacation notices, you might also find that some of your contacts have changed their email addresses due to new jobs or other reasons. You’ll want to search them in your list and replace their email address. (If you delete them and add them as a new contact, you’ll lose the electronic trail of your contact history.)
The Phone Lady told me a nice story about reconnecting with someone as a result of following up on a change notice. The lesson is that you can use this as an opportunity to reach out and touch someone that you haven’t talked to in a while.